Sex-specific body fat distribution predicts cardiovascular ageing.

Vladimir Losev, Chang Lu, Shamin Tahasildar, Deva S Senevirathne, Paolo Inglese, Wenjia Bai, Andrew P King, Mit Shah, Antonio de Marvao, Declan P O'Regan

MRC Laboratory of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK.MRC Laboratory of Medical Sciences, Imperial College London, Hammersmith Hospital Campus, London, UK. · pubmed

Paper

Abstract

Cardiovascular ageing is a progressive loss of physiological reserve, modified by environmental and genetic risk factors, that contributes to multi-morbidity due to accumulated damage across diverse cell types, tissues, and organs. Obesity is implicated in premature ageing, but the effect of body fat distribution in humans is unknown. This study determined the influence of sex-dependent fat phenotypes on human cardiovascular ageing.

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Research summary

The paper claims that sex-specific body fat distribution influences cardiovascular ageing. This research is relevant as it explores the relationship between body fat distribution and cardiovascular ageing, which could provide insights into the mechanisms of aging and potential interventions for age-related diseases.

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