Hydrogen sulfide alleviates vascular smooth muscle cell senescence by inhibiting endoplasmic reticulum stress.

Lijie Jiao, Qiuyi Yan, Jiahe Yang, Ren Wu, Ziyi Wei, Jiawen Ruan, Guoliang Yan, Xu Chen, Hongzhu Li

Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361006, Fujian, China; School of Medicine, Xiamen University, Xiamen 361102, Fujian, China.Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361006, Fujian, China; School of Medicine, Xiamen University, Xiamen 361102, Fujian, China. · pubmed

Paper

Abstract

The senescence of vascular smooth muscle cells (VSMCs) leads to the degeneration of vascular structure and function, as well as age-related cardiovascular diseases. Hydrogen sulfide (H

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Research summary

Hydrogen sulfide alleviates vascular smooth muscle cell senescence by inhibiting endoplasmic reticulum stress. The paper addresses a mechanism related to cellular senescence, which is a key aspect of aging and age-related diseases, thus contributing to the understanding of longevity.

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