SIRT6 Is a Key Regulator of Pancreatic β-Cell Survival and Function During Aging.

Jimin Park, Sandali D Lokuge, Menghao Huang, Shen Wang, Sheng Liu, Jingru Liang, Ramkumar Katturajan, Corinn Marakovits, Zhihong Yang, Jun Wan, X Charlie Dong

Department of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, IN. · pubmed

Paper

Abstract

Pancreatic β-cell function declines with age, but the underlying mechanism is poorly understood. In this study, we attempted to address how to reverse β-cell aging. Our data showed that sirtuin 6 (SIRT6) overexpression can reduce age-associated DNA damage, cell death, and functional decline in β-cells. Our findings suggest that improving Sirt6 gene expression and function may slow down β-cell decline in older patients.

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Research summary

SIRT6 overexpression can reduce age-associated DNA damage and functional decline in pancreatic β-cells. The paper addresses a mechanism related to the aging process in pancreatic β-cells, which is directly relevant to understanding and potentially mitigating age-related decline in cellular function.

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