Advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through RAGE/AKT/mTOR/glycolysis pathway.

Lin Xiong, Jiayu Shu, Hongli Gao, Yufeng Qin, Yuehan Zhang, Xuelian Chang, Qiang Dong, Helin Chen

College of Stomatology of Guizhou Medical University, Guiyang, China.College of Stomatology of Guizhou Medical University, Guiyang, China. · pubmed

Paper

Abstract

Inflammaging plays a pivotal role in the pathogenesis of multiple age-related diseases, including periodontitis. Advanced glycation end products (AGEs) are known to induce inflammaging and exacerbate periodontitis. However, the mechanisms by which AGEs promote inflammaging remain unclear. This study aimed to investigate the mechanisms underlying AGE-induced inflammaging.

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Research summary

The paper claims that advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through the RAGE/AKT/mTOR/glycolysis pathway. This research is relevant as it explores the mechanisms of inflammaging, which is a key factor in the aging process and age-related diseases.

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