A Redox-Active Manganese Nanocluster Reverses Depression-Impaired Bone Regeneration via Targeting Cellular Senescence, Lymphangiogenesis, and the Muscle-Bone Metabolic Axis.

Chen Zhao, Lei Wang, Liyi Zhang, Tinglong Chen, Guantong Sun, Xiaodong Li, Shulan Ma, Xuzhuo Chen, Xiaoqing Wang

Department of Orthopedics, Shanghai Key Laboratory of Orthopedics Implant, the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.Department of Orthopedics, Shanghai Key Laboratory of Orthopedics Implant, the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. · pubmed

Paper

Abstract

Depression, a prevalent chronic psychological disorder in aging populations, is increasingly recognized for its deleterious impact on bone regeneration; yet its pathological mechanisms and targeted therapies remain underexplored. Here, a rationally engineered tetranuclear manganese nanocluster (Mn

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that a manganese nanocluster can reverse depression-impaired bone regeneration by targeting cellular senescence and related pathways. This research is relevant as it addresses the intersection of mental health and physical aging, specifically how depression affects bone regeneration, which is a significant concern in the aging population.

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