Telomere length measures in the Northern Ireland cohort for the longitudinal study of ageing (NICOLA).

Claire Hill, Laura Smyth, Jill Kilner, Katie Quinn, Angie Scott, Charlotte Neville, Frank Kee, Bernadette McGuinness, Amy Jayne McKnight

Centre for Public Health, Queen's University Belfast, Belfast, UK.Centre for Public Health, Queen's University Belfast, Belfast, UK. · pubmed

Paper

Abstract

Using blood derived DNA collected from individuals within the Northern Ireland COhort for the Longitudinal study of Ageing (NICOLA), quantitative real-time polymerase chain reaction (RT-PCR) based absolute telomere length measures were derived in triplicate. This data is generated on a subset of participants (n = 2,971) within the NICOLA cohort at Wave 1 baseline. NICOLA commenced Wave 3 of data collection in Autumn 2024.

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Research summary

The paper claims to derive quantitative telomere length measures from a large cohort. Telomere length is a biomarker associated with cellular aging, making this research relevant to understanding the biological mechanisms of aging.

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