Non-invasive evaluation of advanced glycation end products in hair as early markers of diabetes and aging.
Abstract
Continuous metabolic monitoring is essential for assessing lifestyle-related disease risks. Hair, an easily accessible tissue, allows for long-term metabolic evaluation, with glycated proteins linked to diabetic complications found in hair. We established a mass spectrometry system to detect advanced glycation end products (AGEs) in hair samples from humans and rats, assessing their variations with aging and disease. Hair samples were hydrolyzed and processed using a cation-exchange column for mass spectrometric analysis. Regardless of temperature variations, the levels of AGEs [N
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Research summary
The paper claims that advanced glycation end products in hair can serve as early markers for diabetes and aging. This research is relevant as it explores a potential non-invasive method for monitoring metabolic changes associated with aging and age-related diseases, which could contribute to understanding the biological processes underlying longevity.
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