The cGAS-STING pathway in age-related ocular diseases: Mechanisms and therapeutic opportunities.

Zilin Shang, Di Qin, Xiangnan Liu, Hui Li, Chang Liu, Rui Zhang, Tongyi Sun, Zhifang Pan, Weiguo Feng, Xinguo You

School of Life Science and Technology, Shandong Second Medical University, Weifang 261053, Shandong Province, PR China. · pubmed

Paper

Abstract

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is a crucial component of the innate immune system, which senses abnormal double-stranded DNA in the cytoplasm and induces the type I interferon and pro-inflammatory cytokines expression. In cellular senescence, the cGAS-STING signaling pathway triggers the senescence-associated secretory phenotype, thereby exacerbating the senescence phenomenon and leading to age-related ocular diseases, including age-related macular degeneration and diabetic retinopathy. Herein, we outline the structure of cGAS-STING signaling pathway and its association with cellular senescence, and discuss the mechanism of behavior between cGAS-STING and ocular aging-related diseases. Finally, we summarize the relevant inhibitors of the cGAS-STING signaling pathway, thereby offering a novel direction for exploring the mechanism of ocular aging-related inflammatory diseases.

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Research summary

The paper claims that the cGAS-STING pathway exacerbates cellular senescence, contributing to age-related ocular diseases. This research is relevant as it explores the underlying mechanisms of aging-related processes and potential therapeutic targets, rather than merely addressing symptoms.

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