Aging increases susceptibility to liver fibrosis through enhanced NAT10-mediated ac4C modification of TGFβ1 mRNA.

Xuyun Peng, Panlong Li, Ying Zhang, Qi Zhang, Weicheng Liang

Biotherapy Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China.Biotherapy Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China. · pubmed

Paper

Abstract

The epidemiological observational studies unveiled that aging is one of the risk factors for liver fibrosis, and the hepatic tissues in the elderly harbor more fibrotic lesions when compared to those in young people. Previous investigations found that TGFβ1 was elevated with aging and promoted liver fibrosis. However, the underlying mechanisms of aging and liver fibrosis remain largely unknown.

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Research summary

Aging increases susceptibility to liver fibrosis through enhanced NAT10-mediated ac4C modification of TGFβ1 mRNA. This paper is relevant as it investigates the mechanisms linking aging to liver fibrosis, addressing a potential root cause of age-related disease rather than merely treating symptoms.

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