Data from multi-national aging cohorts show dysregulated metabolic pathways in people with physio-cognitive decline.

Yi-Long Huang, Wei-Ju Chang, Chao-Hsiung Lin, Shu Zhang, Yukiko Nishita, Rei Otsuka, Wei-Ju Lee, Chih-Kuang Liang, Ming-Yueh Chou, Li-Ning Peng, Hidenori Arai, Luigi Ferrucci, Liang-Kung Chen

Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan. · pubmed

Paper

Abstract

Physio-cognitive decline (PCD) represents a dual impairment of mobility and cognitive function in aging populations, significantly increasing risks of disability, dementia, and mortality. Despite its clinical importance, the underlying biological mechanisms driving PCD remain poorly understood. This study aimed to identify metabolomic biomarkers and pathways associated with PCD to elucidate potential mechanistic insights.

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Research summary

The study identifies metabolomic biomarkers and pathways associated with physio-cognitive decline in aging populations. This research is relevant as it seeks to understand biological mechanisms underlying a dual impairment in aging, which could inform strategies for addressing age-related decline.

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