GDF15 is associated with hepatocellular senescence and correlates with mortality in patients with alcohol-associated hepatitis.

Teresa Rubio-Tomás, David Martí-Aguado, Delia Blaya, Silvia Ariño, Beatriz Aguilar-Bravo, Raquel A Martínez García de la Torre, Marc Miravet-Marti, Raquel Ferrer-Lorente, Laura Zanatto, Zengqing Xu, Laura Garcia-Tercero, Carlos Mateos-Sánchez, Juan José Lozano, Isabella Dotti, Johanne Poisson, Marion Tanguy, Azucena Salas, Pierre-Emmanuel Rautou, Ramon Bataller, Pau Sancho-Bru

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. · pubmed

Paper

Abstract

Cellular senescence is characterized by the loss of proliferative capacity, cell cycle arrest, and the acquisition of a proinflammatory senescence-associated secretory phenotype (SASP). Senescence is frequently present in advanced chronic liver diseases; however, the impact of hepatocellular senescence in alcohol-associated liver disease (ALD) progression and alcohol-associated hepatitis (AH) is poorly understood.

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Research summary

The paper claims that GDF15 is associated with hepatocellular senescence and correlates with mortality in patients with alcohol-associated hepatitis. The study addresses cellular senescence in the context of liver disease, which is a significant aspect of aging and age-related diseases, but it primarily focuses on a specific condition rather than broader mechanisms of aging.

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