Disease accumulation and distribution across the lifespan in Swedish centenarians and non-centenarians: a nationwide life course comparison of longevity and health resilience.

Yuge Zhang, Shunsuke Murata, Katharina Schmidt-Mende, Marcus Ebeling, Karin Modig

Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. · pubmed

Paper

Abstract

Previous research suggests that centenarians reach exceptional ages primarily by avoiding major diseases rather than surviving them. However, how they manage multiple conditions over the life course remains less understood. Examining the accumulation and distribution of diseases across lifespan can provide insights into mechanisms underlying their resilience.

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Research summary

Centenarians manage the accumulation and distribution of diseases differently than non-centenarians throughout their lifespan. This paper is relevant as it explores the mechanisms of health resilience in centenarians, contributing to our understanding of longevity and potential pathways to enhance lifespan extension.

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