Top-down engineered micron-cell derived nanovesicles encapsulating curcumin targeting the 3R strategy (remove, remodel, repair) for Alzheimer's disease therapy.

Jianjian Chu, Hui Hu, Wei Xu, Xinyu Lu, Honglei Zhou, Mengqi Hao, Li Wang, Siqi Li, Wenbo Ji, Gang Li, Yi Luo, Jie Gao, Dongya Huang, Yan Liu, You Yin

Department of Neurology, Second Affiliated Hospital (Shanghai Changzheng Hospital) of Naval Medical University, Shanghai, China.Department of Neurology, Second Affiliated Hospital (Shanghai Changzheng Hospital) of Naval Medical University, Shanghai, China. · pubmed

Paper

Abstract

Alzheimer's disease (AD), a global health crisis exacerbated by aging populations, demands innovative therapeutic strategies. Curcumin, a natural compound with anti-aging and anti-inflammatory properties, holds promise for AD treatment but is hindered by poor bioavailability. Here, we developed curcumin-loaded nanovesicles (NV-CUR) derived from brain-homing B16 melanoma cells to overcome these limitations. NV-CUR enhanced the solubility, stability, and blood‒brain barrier (BBB) penetration of curcumin, enabling systemic delivery in aged 3 × Tg AD mice. Our 3R strategy for removing senescent cells, remodeling the neuroinflammatory microenvironment, and repairing neuronal damage was comprehensively validated. NV-CUR effectively cleared p16

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Research summary

The paper claims that curcumin-loaded nanovesicles can effectively target and address the underlying mechanisms of Alzheimer's disease through a 3R strategy. This research is relevant as it explores innovative therapeutic approaches aimed at addressing neurodegeneration, which is a significant aspect of aging and age-related diseases.

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