Cerebrovascular p16

Keiji Kawatani, Tomonori Aikawa, Zeynab Tabrizi, Yining Pan, Yingxue Ren, Ni Wang, Aishe Kurti, Toshihiko Nambara, Clark C Ikezu, Francis Shue, Michael Bamkole, Yasuteru Inoue, Tammee M Parsons, Guojun Bu, Qianqian Song, Oliver Bracko, Takahisa Kanekiyo

Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA. · pubmed

Paper

Abstract

Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive impairment and dementia (VCID) and highly associated with Alzheimer's disease pathogenesis. There is an urgent need to establish relevant animal models for cSVD. As aging is the strongest risk factor for these diseases, cerebrovascular senescence is implicated in cSVD pathogenesis. We investigated how AAV-based expression of senescence marker CDKN2A/p16

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Research summary

The paper investigates the role of cerebrovascular senescence in the pathogenesis of cerebral small vessel disease (cSVD) and its implications for cognitive impairment. This research is relevant as it addresses mechanisms of aging and their contribution to age-related diseases, potentially offering insights into the root causes of cognitive decline.

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