Regulation of transglutaminase-2 and related miRNAs expression by calorie restriction in aorta of aging female mice.

Elif Öztemiz, Soner Dogan, Atakan Ayden, Aysenur Dogan, Nazim Arda Keles, Bilge Guvenc Tuna

Department of Biophysics, School of Medicine, Yeditepe University, Istanbul, Turkey.Department of Biophysics, School of Medicine, Yeditepe University, Istanbul, Turkey. · pubmed

Paper

Abstract

Transglutaminase-2 (TG2) plays a key role in age-related vascular stiffness. This study aims to evaluate the effects of calorie restriction (CR) on TG2 mRNA and protein levels and identify differentially expressed microRNAs (miRNA) predicted to target TG2.

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Research summary

Calorie restriction regulates the expression of transglutaminase-2 and related miRNAs in the aorta of aging female mice. This study addresses the molecular mechanisms underlying vascular aging, which is a significant aspect of longevity research.

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