Ageing-Related Changes in Ultrastructural Bone Matrix Composition and Osteocyte Mechanosensitivity.

Yunxin Chen, Jenneke Klein-Nulend, Nathalie Bravenboer

Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands.Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the Netherlands. · pubmed

Paper

Abstract

Bone matrix is a multiscale composite material mainly composed of collagen, crystalline apatite mineral, water, and a small amount of non-collagenous proteins. Nested within bone matrix, mechanosensitive osteocytes orchestrate bone adaptation to mechanical loading, which is affected by the ultrastructural composition and mechanical properties of the osteocyte-surrounding bone matrix. In this review, we shed light on the impact of ageing-related modifications in ultrastructural composition of bone matrix on the mechanosensitivity of osteocytes.

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Research summary

The paper discusses how ageing-related changes in bone matrix composition affect the mechanosensitivity of osteocytes. This research is relevant as it explores the biological mechanisms underlying aging in bone health, which could contribute to understanding age-related decline and potential interventions.

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