Multi-omic integration of single-cell data uncovers methylation profiles of super-enhancers in skeletal muscle stem cells.

Anyu Zeng, Hailong Liu, Shuling He, Xuming Luo, Zhiqi Zhang, Ming Fu, Baoxi Yu

Department of Bone and Soft Tissue Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510080, P. R. China.Department of Bone and Soft Tissue Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510080, P. R. China. · pubmed

Paper

Abstract

Skeletal muscle stem cells (MuSCs) have strong regenerative abilities, but as we age, their ability to regenerate decreases, leading to a decline in muscle function. Although the methylation reprogramming of super-enhancers (SEs) plays a pivotal role in regulating gene expression associated with the aging process, our understanding of the molecular diversity of stem cells during aging remains limited. This study aimed to identify the methylation profile of SEs in MuSCs and explore potential therapeutic molecular targets associated with aging.

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Research summary

The paper claims to identify the methylation profile of super-enhancers in skeletal muscle stem cells and explore therapeutic targets related to aging. This research is relevant as it addresses the molecular mechanisms underlying the decline in regenerative abilities of muscle stem cells with age, which is a fundamental aspect of the aging process.

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