Deciphering age‑related differences in wound healing: Insights from the interaction between endothelial cells and fibroblasts.

Jianjun Li, Dongzhen Zhu, Mengde Zhang, Zhao Li, Liting Liang, Yuyan Huang, Xu Guo, Yi Kong, Xiaobing Fu, Sha Huang

Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department, PLA General Hospital and PLA Medical College, PLA Key Laboratory of Tissue Repair and Regenerative Medicine, Beijing 100853, P.R. China. · pubmed

Paper

Abstract

Aging impairs wound healing, primarily because of alterations in cell phenotypes and interactions, particularly between endothelial cells (ECs) and fibroblasts (Fibs). The present study investigated the dynamics of EC‑Fib interactions in aged wounds using a mouse model and single‑cell transcriptomics, supplemented by CellChat analysis and functional validation using

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Research summary

The paper investigates the interactions between endothelial cells and fibroblasts in the context of age-related wound healing. This research is relevant as it addresses cellular interactions that contribute to the aging process and could inform strategies for improving healing in aged individuals, thereby potentially impacting longevity.

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