Identification of replicative aging and inflammatory aging signatures via whole-genome CRISPRi screens.

Lingling Wu, Xiang Zhu, Yanxia Liu, Dehua Zhao, Betty Chentzu Yu, Zheng Wei, Xueqiu Lin, Lei S Qi

Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA.Department of Bioengineering, Stanford University, Stanford, CA, 94305, USA. · pubmed

Paper

Abstract

Aging is a major risk factor for chronic diseases and cancer. Cellular aging, particularly in adult stem cells, offers a high-throughput framework for dissecting the molecular mechanisms of aging.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims to identify aging and inflammatory aging signatures through CRISPRi screens. This research is relevant as it aims to dissect the molecular mechanisms of aging, which could contribute to understanding and potentially addressing the root causes of aging.

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