Menopausal status, transition, and age at menopause with accelerated biological aging across multiple organ systems: findings from two cohort studies.

Yi Xiang, Qiong Meng, Zitong Huang, Ning Zhang, Yuan Zhang, Xianbin Ding, Jianhong Yu, Leilei Liu, Xiong Xiao, Xing Zhao

School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. · pubmed

Paper

Abstract

Biological aging is a heterogeneous process that varies across organs and systems. The dynamic hormonal changes during the menopausal transition may have profound and organ-specific impacts on biological aging. However, the relationship between the menopausal transition and both comprehensive and organ-specific biological aging remains poorly understood. This study aimed to investigate the associations between menopausal factors and both comprehensive and organ-specific biological aging, as well as the modifying role of reproductive history.

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Research summary

The paper investigates the associations between menopausal factors and biological aging across multiple organ systems. This research is relevant as it explores the hormonal changes during menopause and their potential impact on biological aging, which aligns with understanding the mechanisms of aging and longevity.

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