Salidroside alleviates cardiomyocyte senescence by activating the AMPK-mediated signaling pathway.

Lan Zhang, Yawei Liu, Zhijuan Hua, Yan Qin, Tao Wang, Na Li, Lei Song

Department of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Hebei University, Baoding, China.Department of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Hebei University, Baoding, China. · pubmed

Paper

Abstract

Cardiovascular aging is a key contributor to cardiovascular diseases (CVDs). As individuals age, the frequency and severity of cardiovascular events rise, establishing CVDs as a primary cause of death in older adults. Therefore, the development and exploration of drugs or bioactive molecules that can effectively prevent cardiovascular aging and related diseases are urgently needed. This study evaluated the effects of salidroside, a key component of Rhodiola rosea extract, on cardiomyocyte senescence. We established an in vitro cardiomyocyte senescence model using D-gal/H

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Research summary

Salidroside activates the AMPK-mediated signaling pathway to alleviate cardiomyocyte senescence. This paper addresses a mechanism related to cardiovascular aging, which is a significant aspect of longevity research.

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