The cell autonomous and non-autonomous functions of Rab27 in longevity and neuroprotection in

Chia-Heng Hsu, Yi-Jhan Li, Ting-Ni Guo, Fei-Yang Tzou, Cheng-Li Hong, Chin-Hsien Lin, Shu-Yi Huang, Chih-Chiang Chan

Graduate Institute of Physiology, National Taiwan University, Taipei, Taiwan. · pubmed

Abstract

Autophagic decline accompanies age and causes a deterioration in proteostasis, rendering neuronal demise. Rab27 functions as a vesicle regulator for macroautophagic/autophagic degradation and exocytosis. Loss of

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Rab27 plays a crucial role in autophagic processes that may influence longevity and neuroprotection. The paper addresses mechanisms related to autophagy, which is a fundamental process in aging and longevity, suggesting potential pathways for intervention in age-related decline.

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