Pelota-mediated ribosome-associated quality control counteracts aging and age-associated pathologies across species.

Jongsun Lee, Bora Lee, Hyein Lee, Eun Ji E Kim, Sieun S Kim, Hyunwoo C Kwon, Hanseul Lee, Gee-Yoon Lee, Woojin Hong, Seokjin Ham, Jae Won Yang, Heeju Park, Tatiana M Moreno, Michelle E Brown, Hae-Eun H Park, Eunah Kim, Yoonji Jung, Eunseok Kang, Sangsoon Park, Yeo Jin Shin, Seokjun G Ha, Sujeong Kwon, Seungjae Hwang, Hyemin Min, Caroline Kumsta, Chunghun Lim, Chanhee Kang, Jinsoo Seo, Kwang-Pyo Lee, Seung-Jae V Lee

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon 34141, South Korea.Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon 34141, South Korea. · pubmed

Paper

Abstract

Ribosome-associated quality control (RQC) is a pivotal biological process that governs the fidelity of messenger RNA (mRNA) homeostasis and protein synthesis. Defects in RQC are implicated in cellular dysfunction and proteotoxicity, but their impact on aging remains elusive. Here, we show that Pelota, the ribosome rescue factor, promotes longevity and protects against age-related pathological phenotypes in multiple metazoan species. By performing a targeted genetic screen, we find that Pelota is indispensable for longevity in the nematode

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Research summary

Pelota promotes longevity and protects against age-related pathological phenotypes across species. The study addresses the role of ribosome-associated quality control in aging, focusing on a mechanism that could potentially mitigate age-related decline, thus contributing to the understanding of longevity and aging processes.

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