Autophagy activator AA-20 improves proteostasis and extends

Ee Phie Tan, Nora Lyang, Saam Doroodian, Pablo Sanz-Martinez, Jin Xu, Sviatlana Zaretski, José L Nieto-Torres, Hiroshi Ebata, Shaun H Y Lim, William C Hou, Khalyd J Clay, Leonard Yoon, Lynée A Massey, Derek Rhoades, Danny Garza, Kristen A Johnson, Alan To, Lydia Ambaye, Emily P Bentley, Michael Petrascheck, Alexandra Stolz, Jeffery W Kelly, Malene Hansen

Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037.Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037. · pubmed

Paper

Abstract

The degradation of cellular components through autophagy is essential for longevity and healthy aging. However, autophagy function decreases with aging, contributing to age-related diseases. In this study, we characterized a small-molecule activator of autophagy called

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Research summary

The paper claims that the small-molecule activator AA-20 enhances autophagy, improving proteostasis and potentially extending lifespan. This research addresses the decline of autophagy with aging, which is a root cause of age-related diseases, making it relevant to longevity and healthy aging.

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