Deletion of METTL14, a key methylation regulator, attenuates vascular ageing.

Xin Liu, Heng Liu, Yuan Lin, Han Lou, Jing Feng, Xiuxiu Sun, Jennifer Wang, Xinxin Dong, Ling Liu, Zeqi Sun, Zijia Dou, Lei Wang, Run Xu, Tong Zhao, Qiang Huang, Wenjie Zhao, Yutong Hao, Limin Zhao, Baofeng Yang, Yong Zhang

State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology, College of Pharmacy, and Department of Cardiology, The Second Affiliated Hospital, Harbin Medical University, 157 Baojian Road, Harbin 150081, China.State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology, College of Pharmacy, and Department of Cardiology, The Second Affiliated Hospital, Harbin Medical University, 157 Baojian Road, Harbin 150081, China. · pubmed

Paper

Abstract

Vascular ageing often accompanies inflammation, contributing to the onset of local or systemic vascular diseases. Nevertheless, limited research focuses on pivotal factors triggering chronic vascular inflammation and associated pathological changes. This study aimed to investigate the role of methyltransferase-like protein 14 (METTL14) in inflammation in the pathogenesis of vascular ageing.

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Research summary

Deletion of METTL14 reduces inflammation associated with vascular ageing. The study addresses a key factor in the mechanisms of vascular ageing, which is directly related to the biological processes of aging and potential interventions for age-related diseases.

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