The transcriptome of the olm provides insights into its evolution and gene expression.

Susanne Holtze, Defne Demirtürk, Oliver Ohlenschläger, Simon Hegele, Kanstantsin Siniuk, Silke Förste, Venket Raghavan, Marco Groth, Martin Bens, Nils Hassel, An Martel, Maja Lukač, Ivan Cizelj, Martin Fischer, Hequn Liu, Thomas B Hildebrandt, Steve Hoffmann, Arne Sahm

Department of Reproduction Management, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany. [email protected] of Reproduction Management, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany. [email protected]. · pubmed

Paper

Abstract

The olm (Proteus anguinus), with a predicted maximum lifespan of more than 100 years, is the longest-lived amphibian, which in addition possesses a range of unique adaptations to its dark, subterranean cave habitat. To assess the underlying molecular signatures, we present the first comprehensive transcriptome of the olm. Our study provides gene expression data across six organs and comparative genomics analyses, accessible via an interactive web server: http://comp-pheno.de/olm . The data uncover significant organ-specific gene expression, with the brain showing the highest number of organ-specific expressed genes. Our findings reveal significantly more genes under strong negative selection than positive selection, particularly in brain-specific expressed genes. Processes under positive selection in the olm resemble those in other long-lived species.

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Research summary

The paper claims to provide insights into the gene expression and evolutionary adaptations of the olm, particularly in relation to its longevity. The research is relevant as it explores the molecular basis of longevity in a long-lived species, potentially shedding light on mechanisms that could inform aging research.

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