Chrysin ameliorates D-galactose-induced liver aging in mice: the impact of targeting Nrf2/AKT and CXCL1/TNF-α/P53 signaling pathways.
Abstract
Liver aging is a major cause of death all over the world. D-galactose (D-gal) induces liver aging via inflammatory pathways in Kupffer cells. Chrysin (CHR) is a flavonoid having anti-inflammatory and antioxidant effects that can protect liver from aging responses. This study aimed to clarify the hepatoprotective activity of CHR in D-gal-induced liver aging.
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Research summary
Chrysin ameliorates liver aging in mice by targeting specific signaling pathways. The study addresses the mechanisms of liver aging, which is a fundamental aspect of the aging process, rather than merely treating symptoms of age-related diseases.
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