Disturbed engram network caused by NPTX downregulation underlies aging-related contextual fear memory deficits.

Tao Jin, Yang Yang, Yu Guo, Yi Zhang, Qiumin Le, Nan Huang, Xing Liu, Jintai Yu, Lan Ma, Feifei Wang

School of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.School of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. · pubmed

Paper

Abstract

Engram cells storing episodic memories are allocated to separate neuronal ensembles. However, how these ensembles maintain their stability to drive precise memory expression, and whether their destabilization contributes to aging-related memory deficits, remain elusive. Here, we show that during contextual fear memory consolidation, neuronal pentraxin 1 (NPTX1) in Fos transcription-dependent ensemble (F-RAM) of the dentate gyrus (DG) promotes memory expression in the fear context. NPTX1 facilitates K

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Research summary

The paper claims that downregulation of NPTX1 in specific neuronal ensembles contributes to aging-related deficits in contextual fear memory. This research is relevant as it explores the mechanisms underlying memory decline associated with aging, potentially addressing root causes of cognitive decline in the elderly.

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