CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity.

Manuel M Gómez de Las Heras, Elisa Carrasco, Mario Pérez-Manrique, Naohiro Inohara, Sandra Delgado-Pulido, Álvaro Fernández-Almeida, María I Gálvez-Castaño, Isaac Francos-Quijorna, Carolina Simó, Virginia García-Cañas, José Ignacio Escrig-Larena, Juan Francisco Aranda, Gonzalo Soto-Heredero, Enrique Gabandé-Rodríguez, Eva María Blanco, Joyce Días-Almeida, Gabriel Núñez, María Mittelbrunn

Tissue and Organ Homeostasis Program, Centro de Biología Molecular Severo Ochoa (CBM), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad Autónoma de Madrid (UAM), Madrid, Spain. · pubmed

Paper

Abstract

Healthy aging relies on a symbiotic host-microbiota relationship. The age-associated decline of the immune system can pose a threat to this delicate equilibrium. In this work, we investigated how the functional deterioration of T cells can affect host-microbiota symbiosis and gut barrier integrity and the implications of this deterioration for inflammaging, senescence, and health decline. Using the

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Research summary

The paper claims that CD4 T cell therapy can preserve gut barrier integrity, counteracting inflammaging and senescence. This research addresses the functional deterioration of T cells and its impact on aging, which is directly related to the root causes of aging and age-related decline.

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