Exogenous Nucleotides Supplementation Attenuates Age-Related Sarcopenia.

Xin Wu, Rui Liu, Na Zhu, Xiujuan Wang, Chan Wei, Xiaoyang An, Meihong Xu, Yong Li

Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, China.Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing, China. · pubmed

Paper

Abstract

Sarcopenia, an age-related clinical syndrome characterized by reduced skeletal muscle mass and strength, often leads to a loss of physical function. Nucleotides (NTs) supplementation is a potential strategy for preventing age-related sarcopenia as evidence suggests that NTs declined in muscles with aging, and 5'-CMP, 5'-UMP can mitigate muscle atrophy in C2C12 myotubes. This study aimed to investigate the effects of NTs supplementation on sarcopenia and its possible mechanism.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Nucleotide supplementation can mitigate age-related sarcopenia by addressing the decline of nucleotides in aging muscles. This research is relevant as it explores a potential intervention that targets a specific aspect of aging, namely the loss of muscle mass and strength, which is a significant contributor to overall health and longevity in the elderly.

Author of this paper? Send a correction.