Trajectories of intrinsic capacity during ageing: the longitudinal aging study Amsterdam.

Yuwei Qi, Trynke Hoekstra, Natasja M van Schoor, Laura Schaap

Amsterdam UMC location Vrije Universiteit Amsterdam, Epidemiology and Data Science, Amsterdam Public Health Research Institute, Aging and Later Life, the Netherlands. Electronic address: [email protected]. · pubmed

Paper

Abstract

Intrinsic capacity (IC), as defined by the World Health Organization (WHO), represents an individual's physical and mental capacities across five domains: locomotion, cognition, vitality, psychology, and sensory. As a key determinant of functional ability (FA), IC supports meaningful activities, and its decline predicts FA deterioration. Monitoring IC over time may help detect early decline and guide interventions. However, it is not clear how (domains of) IC change during normal ageing. Therefore, this study aimed to identify IC trajectories in both women and men and their associations with functional limitation (proxy of FA) and Quality of Life during ageing.

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Research summary

The study identifies trajectories of intrinsic capacity during ageing and their associations with functional limitation and quality of life. This research is relevant as it explores the decline of intrinsic capacity, which is a key determinant of functional ability and overall health during aging, potentially informing interventions to improve longevity and quality of life.

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