Role of Prohibitins as Guardians of mitochondrial homeostasis.
Abstract
Mitochondria are complex organelles critical to the maintenance of cellular homeostasis. Central to this regulation are Prohibitins (PHBs), a novel set of proteins involved in several mitochondrial quality control pathways, including protein folding, biogenesis, and mitophagy. PHBs mediate various cellular responses including cell survival and myogenesis, suggesting that their roles are intricate and multifaceted. While evidence suggests that PHBs facilitate mitochondrial homeostasis, their exact mechanism of action remains unclear. Elucidating the precise mechanisms driving PHB-mediated adaptations will ultimately enable the development of therapeutic strategies aimed towards the treatment of age-related diseases, characterized by mitochondrial perturbations.
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Research summary
Prohibitins play a crucial role in maintaining mitochondrial homeostasis, which is essential for cellular health and longevity. The paper is relevant as it explores the mechanisms by which PHBs contribute to mitochondrial function, potentially addressing root causes of age-related diseases linked to mitochondrial dysfunction.
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