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RESEARCH PAPER / 2025-07-30

Healthy lifestyle and life expectancy with and without major chronic disease - a cohort study.

Anne Kirstine Eriksen, Kathrine Grell, Peter Fjeldstad Hendriksen, Jan Wohlfahrt, Anne Tjønneland, Anja Olsen

Diet, Cancer and Health, Danish Cancer Institute, Copenhagen, Denmark. [email protected], Cancer and Health, Danish Cancer Institute, Copenhagen, Denmark. [email protected]. · pubmed

Abstract

Health behaviors affect life expectancy, but whether disease is present can greatly impact both the individual and society. How health behavior is reflected in the utilization of health care services is yet to be investigated to support the impact of prevention efforts. Based on data from 57,053 middle-aged individuals from the Danish Diet, Cancer and Health cohort, a health score including baseline smoking status, sport activity, alcohol consumption, diet, and waist circumference was constructed as a simple measure of general health behavior. During 20 years of follow-up, healthy life expectancy among men and women aged 65 years at baseline, was 0.83 [0.74 to 0.92] and 0.86 [0.77 to 0.94] years longer on average, respectively, per one point increment in the health score. Life expectancy with disease was shorter among men (-0.18 [-0.26 to -0.09]) and women (-0.37 [-0.45 to -0.29]) with higher health scores. Among individuals with the highest scores, major chronic disease diagnosis was postponed for more than 7 years. There were fewer disability years, especially with multimorbidity, (men: -1.6 years; women: -3.3 years), and there was a clear inverse association between health score and days of hospitalization looking 20 years ahead.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Health behaviors significantly influence life expectancy and the onset of major chronic diseases. The study provides insights into how lifestyle choices can extend healthy life expectancy and delay chronic disease, which is pertinent to understanding longevity and aging.

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