Promoting ROS scavenging and osteogenic differentiation by metal-phenolic network nanoparticle-embedded microenvironment-responsive hydrogel for the repair of senile osteoporotic bone defects.

Sixu Zhang, Sixian Zhang, Wenwen Fan, Changsheng Liu, Xi Chen

Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China. [email protected]. · pubmed

Paper

Abstract

Senile osteoporosis (SOP) features reduced bone density and degraded trabecular structure, primarily mediated through senescent impairment of osteoblasts that disrupts coupled bone remodeling homeostasis. This pathological process induces systemic bone resorption and localized bone destruction accompanied by architectural deterioration. Existing treatments for senile osteoporosis tend to focus on a single mechanism, making it challenging to simultaneously address bone formation deficits and oxidative stress. Herein, we developed a multifunctional nanoplatform utilizing metal-phenolic networks (MPNs), formed

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Research summary

The paper claims to develop a multifunctional nanoplatform that promotes ROS scavenging and osteogenic differentiation to repair senile osteoporotic bone defects. This research addresses the underlying mechanisms of bone density loss and oxidative stress associated with aging, which are critical factors in longevity and age-related diseases.

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