Co-regulation of Nr1d1 and Pparα in age-related changes of lipid metabolism and its modulation by calorie restriction.

Sang Gyun Noh, Hyun Woo Kim, Seungwoo Kim, Byung Pal Yu, Jeong-Hyun Yoon, Ki Wung Chung, Jaewon Lee, Hae Young Chung

Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea. · pubmed

Paper

Abstract

Aging is associated with a decline in liver function, which increases the risk of age-related metabolic disorders. Calorie restriction (CR) counteracts age-related changes in the liver; however, the underlying molecular mechanism remains elusive. In this study, we integrated transcriptomic, bioinformatic, and molecular analyses to investigate the effects of aging and CR on age-related gene expression in the rat liver, focusing on the interplay between the circadian rhythm and lipid metabolism. Our results revealed aging-induced upregulation of

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Research summary

The paper claims that calorie restriction modulates age-related changes in lipid metabolism through the co-regulation of Nr1d1 and Pparα. This research is relevant as it investigates molecular mechanisms underlying aging and potential interventions that could mitigate age-related metabolic decline.

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