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RESEARCH PAPER / 2025-07-29

Frailty subtypes and white matter alterations in older adults without dementia.

Chen-Hua Lin, Yah-Ting Wu, Jun-Ying Wei, Yao-Chia Shih, Yi-Ping Chao, Yen-Jun Lai, Yen-Ling Chiu, Yi-Fang Chuang

Institute of Public Health, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.Institute of Public Health, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. · pubmed

Abstract

Frailty increases the risk of cognitive decline in older adults, yet the brain structural patterns associated with different frailty subtypes remain unclear. This study examined white matter (WM) alterations across frailty subtypes in community-dwelling older adults without dementia.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The study investigates the relationship between frailty subtypes and white matter alterations in older adults without dementia. This research is relevant as it explores the underlying brain structural changes associated with frailty, which is a significant factor in aging and cognitive decline.

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