S913 phosphorylation of Ulk1 protects the heart from aging through inhibition of cardiac senescence.

Peiyong Zhai, Eun-Ah Sung, Koichiro Takayama, Soichiro Ikeda, Masato Matsushita, Yasuki Nakada, Yimin Tian, Junichi Sadoshima

Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers-New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103. · pubmed

Paper

Abstract

We have previously shown that prevention of GSK-3β inactivation with GSK-3β (S9A), stimulates autophagy through phosphorylation of Ulk1 at Ser913. In the current study, we investigated whether cardiac aging is accelerated in Ulk1S913A knock in mice and whether cardiomyocyte senescence plays an important role in the development of aging cardiomyopathy in these mice.

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Research summary

The study claims that phosphorylation of Ulk1 at Ser913 protects the heart from aging by inhibiting cardiac senescence. This research is relevant as it addresses mechanisms that may contribute to the aging process and age-related cardiac dysfunction, focusing on cellular senescence as a root cause of aging in the heart.

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