Circulating miR-144-3p as a Novel Independent Biomarker Associated With Low Muscle Strength Among Older Adults.

Hyung Eun Shin, Chang Won Won, Gustavo Duque, Miji Kim

Department of Health Sciences and Technology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.Department of Health Sciences and Technology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea. · pubmed

Paper

Abstract

Low muscle strength, a key component of sarcopenia, is significant in the development of adverse health outcomes among older adults. MicroRNAs (miRNAs) have been implicated in mechanisms of sarcopenia; however, their specific functions in sarcopenia components, particularly low muscle strength, remain unclear. We aimed to examine distinct miRNA signatures associated with muscle mass, strength, and performance and to explore independent biomarkers for identifying older adults with low muscle strength.

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Research summary

Circulating miR-144-3p is associated with low muscle strength in older adults. The study addresses a specific aspect of sarcopenia, which is a significant contributor to aging-related health decline, thus making it relevant to longevity research.

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