Ageing-associated endothelial decorin induction and the impact of non-glycanated decorin on cardiac inflammation.

Guillermo Luxán, Timm Winkelmeier, Colin Bodemer, Büşra Nur Toğru, Mariana Shumliakivska, Marion Muhly-Reinholz, Ariane Fischer, Mariano Ruz Jurado, David John, Wesley T Abplanalp, Stefanie Dimmeler

Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Frankfurt am Main, Germany.Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Frankfurt am Main, Germany. · pubmed

Paper

Abstract

Cardiovascular disease is the leading cause of death in the European Union and aging is one of its major risk factors resulting in the progressive deterioration of the cardiac structures and function. Here, we have combined single-nucleus-RNA-sequencing, imaging, and molecular and cell biology approaches to explore the maladaptive signals that drive cardiac ageing.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper investigates the role of endothelial decorin induction in cardiac inflammation associated with aging. This research is relevant as it addresses mechanisms underlying cardiac aging, which is a significant aspect of age-related diseases and longevity.

Author of this paper? Send a correction.