Human umbilical cord-derived mesenchymal stromal cell exosomes ameliorate aging-associated skeletal muscle atrophy and dysfunction in SAMP10 mice.

Zhe Huang, Limei Piao, Xiangkun Meng, Aiko Inoue, Kazuhiro Hitomi, Hiroyuki Umegaki, Masafumi Kuzuya, Xian Wu Cheng

Department of Human Life Cord Applied Cell Therapy, Nagoya University Graduate School of Medicine, Nagoya, Aichi-Ken, 466-8550, Japan.Department of Human Life Cord Applied Cell Therapy, Nagoya University Graduate School of Medicine, Nagoya, Aichi-Ken, 466-8550, Japan. · pubmed

Paper

Abstract

Loss of skeletal muscle mass and function in aging individuals is closely linked to physical deterioration and disability. Because exosomes of human umbilical cord-derived mesenchymal stem cells (hucMSC-Exos) have been widely used to treat various human diseases, we examined their effects on aging-associated muscle atrophy and dysfunction in senescence-accelerated mouse prone 10 (SAMP10) mice, an animal model of human Sarcopenia.

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Research summary

The paper claims that human umbilical cord-derived mesenchymal stromal cell exosomes can improve aging-associated skeletal muscle atrophy and dysfunction. This research is relevant as it explores a potential therapeutic approach to address the underlying issues of muscle deterioration in aging, which is a significant aspect of longevity and age-related health decline.

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