The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life.

M Hafiz Rothi, Gautam Chandra Sarkar, Joseph Al Haddad, Wayne Mitchell, Kejun Ying, Nancy Pohl, Roberto G Sotomayor-Mena, Julia Natale, Scarlett Dellacona, Vadim N Gladyshev, Eric Lieberman Greer

Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston, MA, USA.Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston, MA, USA. · pubmed

Paper

Abstract

Specialized ribosomes help determine which proteins are synthesized, however, the influence of age on ribosome heterogeneity and whether dysregulation of this process drives organismal aging is unknown. Here we examined the role of ribosomal RNA (rRNA) methylation in maintaining appropriate translation as organisms age. In a directed RNAi screen, we identified 18S rRNA N6'-dimethyl adenosine (m

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Research summary

The paper claims that the 18S rRNA methyltransferase DIMT-1 plays a role in regulating lifespan in the germline later in life. This research is relevant as it investigates the mechanisms of ribosomal RNA methylation and its impact on aging, potentially addressing root causes of lifespan regulation.

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