Wen-Shen-Tong-Luo-Zhi-Tong Decoction alleviates bone loss in aged mice by suppressing LONP1-mediated macrophage senescence.

Qinfeng Zhou, Kaixuan Wang, Cong Wang, Xiaoxian Sun, Lining Wang, Jie Sun, Yalan Pan, Muzhe Li, Zitong Zhao, Shijie Zhou, Qing Wang, Yafeng Zhang, Yong Ma, Yang Guo

Laboratory of New Techniques of Restoration & Reconstruction of Orthopedics and Traumatology, Nanjing University of Chinese Medicine, Nanjing, China.Laboratory of New Techniques of Restoration & Reconstruction of Orthopedics and Traumatology, Nanjing University of Chinese Medicine, Nanjing, China. · pubmed

Paper

Abstract

Aging leads to senile osteoporosis (SOP), marked by bone loss and increased fracture risk. Macrophages, as active immune cells in bone tissue, play an important role in osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) during aging. Wen-Shen-Tong-Luo-Zhi-Tong Decoction (WSTLZTD), a traditional Chinese herbal formula, has been clinically validated for its efficacy in treating SOP. However, the specific mechanisms by which WSTLZTD exerts its anti-SOP effects-particularly through modulating macrophage senescence-remain unclear.

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Research summary

Wen-Shen-Tong-Luo-Zhi-Tong Decoction alleviates bone loss in aged mice by suppressing macrophage senescence. The paper is relevant as it explores a potential intervention targeting the mechanisms of aging, specifically addressing macrophage senescence and its role in age-related bone loss.

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