Skin microbiome and skin aging: emerging strategies for manipulation.

Zhiyan Wang, Fengming Yuan, Xuewei Zhong, Shi Feng, Tao Song

Center for Cleft Lip and Palate Treatment, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 33 Ba-da-chu Road, Beijing 100144, China. Electronic address: [email protected] for Cleft Lip and Palate Treatment, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 33 Ba-da-chu Road, Beijing 100144, China. Electronic address: [email protected]. · pubmed

Paper

Abstract

As the global population ages, the prevention and treatment of skin aging have become critical areas of scientific research. The aging process of the skin leads to a decline in immune function and a reduced capacity for self-repair. Skin aging is driven by various factors, including intrinsic elements (such as genetic predispositions and biological aging), and extrinsic factors (notably ultraviolet radiation). Recent studies have highlighted the crucial role of the skin microbiome in maintaining skin health and regulating the aging process. This review emphasizes the impact of biological aging and ultraviolet radiation, alongside the gut-skin axis, on skin aging. Furthermore, it explores current microbiome-based therapeutic strategies aimed at decelerating skin aging and discusses the potential of the skin microbiome in predicting biological and systemic aging-related diseases. These insights deepen our understanding of the mechanisms by which the skin microbiome influences aging and lay the groundwork for novel interventions in this field.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that manipulating the skin microbiome can decelerate skin aging and potentially predict aging-related diseases. This research is relevant as it explores the role of the skin microbiome in the aging process, addressing underlying mechanisms that could contribute to longevity and age-related health improvements.

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