M6PR upregulation by berberine attenuates hepatic senescence via sorting STING into endosome for degradation.

Wenjuan Tang, Qianqian Zhang, Longyu Qin, Xinxin Yang, Dake Chu, Han Li, Jiaqi Zhang, Yanmin Zhang, Hongmei Zhang

Department of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China; State Key Laboratory of Shaanxi for Natural Medicines Research and Engineering, Xi'an, Shaanxi, 710061, PR China. · pubmed

Paper

Abstract

Cellular senescence is associated with various hepatic diseases. Stimulator of interferon genes (STING) signaling has been identified as a significant driver of cellular senescence and hepatic stellate cells (HSCs) activation. The blockade of STING signaling serves as a potential strategy to halt senescence. However, little is known about the anti-aging natural compound inhibiting STING signaling to date.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Berberine upregulates M6PR to attenuate hepatic senescence by promoting the degradation of STING. This research addresses a mechanism related to cellular senescence, which is a fundamental aspect of aging and age-related diseases.

Author of this paper? Send a correction.