Synergistic Effects of Activatable Photodynamic Therapy and Crisaborole for Psoriasis through Senolysis and Immunomodulation.

Yangxin Yu, Xinhang Lv, Zhuowei Chen, Xiaokang Li, Liru Chen, Youyou Chen, Wenhui Gu, Xiantao Zhou, Jian Li, Donglei Shi

Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, Hainan, P. R. China. · pubmed

Paper

Abstract

Psoriasis is a multifactorial inflammatory disorder characterized by therapeutic resistance and high recurrence rates, with complex unmet clinical demands necessitating novel therapeutic strategies. Recently, emerging evidence has revealed pathological accumulation of senescent cells (SnCs) in psoriatic lesions, suggesting their critical involvement in disease persistence and relapse. Our previous studies demonstrated that precision photodynamic therapy (PDT) effectively eliminates SnCs and mitigates senescence-associated pathologies, positioning senotherapy as a potential breakthrough for psoriasis management. Building on these foundations, we developed SnC-targeted photosensitizers (H

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Research summary

The paper claims that combining activatable photodynamic therapy with Crisaborole can effectively target and eliminate senescent cells in psoriasis, leading to improved treatment outcomes. This research is relevant as it addresses the accumulation of senescent cells, which is a key factor in aging and age-related diseases, suggesting a potential therapeutic strategy that could impact longevity.

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