Disruption of ZC3H15 compromises telomere length maintenance by entrapping telomerase within cajal bodies.

Chuanle Wang, Wei Chen, Ruofei Li, Yue Yang, Jiali Wu, Yuyang Tian, Zibin He, Song Lin, Xining Wang, Jianxi Zhu, Wenbin Ma, Zhou Songyang, Yan Huang

MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol and Guangzhou Key Laboratory of Healthy Aging Research, School of Lifesciences, Sun Yat-Sen University, Guangzhou, 510275, China.MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol and Guangzhou Key Laboratory of Healthy Aging Research, School of Lifesciences, Sun Yat-Sen University, Guangzhou, 510275, China. · pubmed

Paper

Abstract

Telomere homeostasis is pivotal in various biological processes including ontogeny, reproduction, physiological aging, and the onset of numerous diseases such as tumors. In human stem cells and approximately 85% of tumor cells, telomerase formed by TERT and TERC RNA complex is responsible for elongating telomeres. However, the intricate and precise regulatory mechanisms governing telomerase remain largely elusive.

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Research summary

Disruption of ZC3H15 leads to compromised telomere length maintenance due to telomerase entrapment within Cajal bodies. The study addresses telomere maintenance, which is crucial for cellular aging and longevity, thereby contributing to our understanding of the mechanisms underlying aging and age-related diseases.

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