Identification and validation of the pivotal role of MANF gene in pancreatic β-cell aging using bioinformatics.

Jiang Liu, Yaodong Wang, Junqi Yang, Xiaowu Dong, Qingtian Zhu, Chenchen Yuan, Bailai Jiang, Guotao Lu, Weixuan Yang, Yumin Ma

Department of Endocrinology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.Department of Endocrinology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China. · pubmed

Paper

Abstract

Pancreatic β-cells are essential for maintaining endocrine function, and their age-related decline is strongly associated with insulin resistance and an increased risk of developing diabetes. By integrating cross-species bioinformatics analyses (single-cell RNA-seq data from young and aged cynomolgus macaques and microarray data from young and old mouse pancreatic β-cells), we identified mesencephalic astrocyte-derived neurotrophic factor (MANF), an endoplasmic reticulum (ER) stress-related gene, as a key regulator of β-cell aging. Using a d-galactose (D-gal)-induced aging mouse model (400 mg/kg/day for 10 weeks) and H

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Research summary

The paper claims that the MANF gene is a key regulator of pancreatic β-cell aging. This research is relevant as it addresses a potential root cause of aging in pancreatic β-cells, which is crucial for understanding age-related metabolic diseases like diabetes.

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