The Association of a Polygenic Lifespan Score With the Risk of Common Age-Related Diseases and Mortality.

Niko Paavo Tynkkynen, Kaisa Koivunen, Päivi Herranen, Laura Joensuu, Timo Törmäkangas, Elina Sillanpää

Faculty of Sport and Health Sciences, Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland.Faculty of Sport and Health Sciences, Gerontology Research Center, University of Jyväskylä, Jyväskylä, Finland. · pubmed

Paper

Abstract

Aging increases the risk of major noncommunicable diseases. Research into the genetics of health-related traits could reveal genetic pathways for robustness against these diseases. We studied how a genetic predisposition for a long lifespan is associated with the risk of all-cause mortality and major age-related noncommunicable diseases.

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Research summary

The paper claims that a polygenic lifespan score is associated with the risk of all-cause mortality and major age-related diseases. This research explores genetic predispositions related to longevity, which is directly relevant to understanding the biological mechanisms of aging and potential interventions for lifespan extension.

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