Multiomic identification of senescent stem cell populations critical for osteoarthritis progression and therapy in subchondral bones.

Pei Lin Li, Jie Tang, Xiao Tong Li, Shi Rong Zhao, Run Xiang Xu, Zhi Dong Zhao, Zhong Li Li, Zhi Ling Li, Bo Feng Yin, Fu Hao Yu, Chu Tse Wu, Heng Zhu

Department of Stem Cells and Regenerative Medicine, Beijing Institute of Radiation Medicine, Road Taiping 27, Beijing 100850, P.R. China.Department of Stem Cells and Regenerative Medicine, Beijing Institute of Radiation Medicine, Road Taiping 27, Beijing 100850, P.R. China. · pubmed

Paper

Abstract

Osteoarthritis (OA) is a challenging degenerative joint disease with limited treatment options. Subchondral bone plays a critical role in maintaining joint homeostasis and influencing OA progression. Here, we investigated the role of senescence in mesenchyme-derived stem/progenitor cells (MDSPCs) during OA progression, aiming to identify potential therapeutic targets. Histopathological evaluations and bioinformatic analyses of OA samples from both humans and mice revealed that EGFR

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Research summary

The paper identifies senescent mesenchyme-derived stem/progenitor cells as critical for osteoarthritis progression and potential therapeutic targets. This research addresses the role of cellular senescence in a degenerative disease, linking it to aging processes and potential interventions that could impact longevity.

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