The Association Between Weight-Adjusted-Waist Index and S-Klotho Levels in Adults: NHANES 2007-2016.

Jingjing Chen, Qingyi Zeng, Li Liu, Yilan Li, Anning Wang, Yingqi Yi, Zhanglan Wang, Weihong Sun, Wei Zhou, Yun Ye, Wei Li

Department of Cardiovascular Medicine Affiliated Hospital of Guizhou Medical University Guiyang China.Department of Cardiovascular Medicine Affiliated Hospital of Guizhou Medical University Guiyang China. · pubmed

Paper

Abstract

The weight-adjusted waist index (WWI) is a new obesity metric that may better reflect body fat distribution than traditional measures like body mass index (BMI). However, the link between WWI and serum Klotho levels, an aging biomarker, is not well understood. The study involved non-pregnant adults aged 40 to 79 years who had comprehensive data regarding BMI, waist circumference (WC), and serum Klotho levels. We analyzed data from 12,809 participants aged 40 to 79 years from NHANES. WWI was calculated by dividing WC by the square root of body weight. Participants were categorized into quartiles based on WWI values. A multivariate linear regression model assessed the relationship between WWI and serum Klotho levels, with subgroup analyses for demographic consistency. The analysis showed a significant negative correlation between WWI and serum Klotho levels (

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Research summary

The study claims that there is a significant negative correlation between weight-adjusted waist index and serum Klotho levels in adults. This paper is relevant as it explores a potential link between a new obesity metric and an aging biomarker, contributing to the understanding of factors that may influence aging processes.

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